Triglycerides

Triglycerides are circulating blood lipids that serve as the body’s primary energy reservoir, stored in fat tissue and mobilized as needed. Elevated levels may indicate insulin resistance or pancreatic dysfunction and have been independently associated with adverse cardiovascular outcomes in published literature.[38] [39] Genetic (Mendelian randomization) studies have been used to investigate the role of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease. [40] [41] The 2025 AHA/ACC guidelines include elevated triglycerides as a risk-enhancing factor for primary prevention and define hypertriglyceridemia as ≥150 mg/dL.[23] The VMR thresholds reported here are derived from VH statistical models and are not clinical treatment targets.

[38]Laufs U, Parhofer KG, Ginsberg HN, Hegele RA. Clinical review on triglycerides. Eur Heart J. 2020;41(1):99-109c. doi:10.1093/eurheartj/ehz785

[39]Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the Risk of Coronary Heart Disease. Circulation. 2007;115(4):450-458. doi:10.1161/CIRCULATIONAHA.106.637793

[40]Jørgensen AB, Frikke-Schmidt R, West AS, Grande P, Nordestgaard BG, Tybjærg-Hansen A. Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction. Eur Heart J. 2013;34(24):1826-1833. doi:10.1093/eurheartj/ehs431

[41]Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease | Circulation Research. Accessed November 6, 2025. https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.306249?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

[23]2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Hypertension. Accessed November 6, 2025. https://www.ahajournals.org/doi/10.1161/HYP.0000000000000249#sec-6