Inflammation Health

Inflammatory Health

For inflammatory health, we model and predict the 15-year probability of elevated GDF15, a biomarker associated in published literature with inflammation and cellular stress. Persistently elevated GDF15 levels have been reported to be associated with cardiovascular disease, metabolic dysfunction, and accelerated biological aging.[13] GDF15 is used as a surrogate marker for inflammatory burden. It is not a diagnostic endpoint for any specific disease, and associations reported in this section should not be interpreted as evidence that GDF15 causes clinical disease in an individual.

Chronic low-grade inflammation is recognized as a key contributor to atherosclerosis and other forms of cardiovascular disease. Inflammaging, the gradual acceleration of aging driven by persistent inflammation, may also play a significant role in several chronic age-related conditions affecting the brain, heart, and kidneys, including dementia, type 2 diabetes, and kidney disease.[14]

Below are values for our model’s most predictive biomarkers for GDF15 in males and females aged 40 to 70.

Inflammationvmr

The tables below contain inflammatory health risk multipliers (RM) for each of the above biomarkers.

Cognitiverr

[13]di Candia AM, de Avila DX, Moreira GR, Villacorta H, Maisel AS. Growth differentiation factor-15, a novel systemic biomarker of oxidative stress, inflammation, and cellular aging: Potential role in cardiovascular diseases. Am Heart Hournal Plus Cardiol Res Pract. 2021;9:100046. doi:10.1016/j.ahjo.2021.100046

[14]Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023;8(1):239. doi:10.1038/s41392-023-01502-8